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3Differential Diagnostic Topics14 min read

Differential diagnosis of consciousness disturbances

1. Big picture

Disturbance of consciousness is an emergency symptom, not a diagnosis. The examiner expects a safe clinical algorithm:

Airway, Breathing, Circulation → check glucose immediately → look for focal neurological signs/trauma/infection/toxins/metabolic causes → treat reversible killers while investigating.

The most dangerous mistakes are:

  • forgetting hypoglycemia,
  • missing stroke/intracranial bleeding,
  • missing sepsis/meningitis,
  • missing CO₂ narcosis/hypoxia,
  • treating “confusion” as psychiatric before excluding organic disease.

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