General features of systemic autoimmune diseases

1. Big picture

Systemic autoimmune diseases are chronic immune-mediated diseases in which the immune system loses tolerance to self-antigens and causes multiorgan inflammation. They are exam-important because they often present with vague symptoms first — fatigue, fever, arthralgia, Raynaud phenomenon, rash, sicca symptoms, cytopenias, proteinuria — and the task is to recognize the systemic pattern, order the right autoantibodies, assess organ damage, and treat according to severity.

Core exam idea: Do not diagnose systemic autoimmune disease from one positive antibody. Diagnose it by combining:

**clinical pattern + inflammatory markers + autoantibodies + organ involvement + ex