Special types of multiple sclerosis
1. Big picture
“Special types of multiple sclerosis” is an older exam-style topic that includes atypical inflammatory demyelinating diseases of the central nervous system. Some of these were historically grouped with MS, but modern neurology separates several of them from true MS.
The most important exam distinction:
Typical MS is a chronic CNS demyelinating disease with dissemination in space and time. Special variants/mimics may be acute, monophasic, fulminant, tumor-like, antibody-mediated, or restricted mainly to optic nerve and spinal cord.
The most important entities are:
- Tumefactive MS
- Marburg variant
- Baló concentric sclerosis
- **Schilder
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