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39General Pediatrics22 min read

Primary and secondary immune deficiencies in children

1. Big picture

Immune deficiency in pediatrics means the child’s immune system cannot protect normally against infection. The exam question usually gives you a child with recurrent, severe, unusual, persistent, or treatment-resistant infections.

Core clinical pattern:

Too many infections + severe infections + unusual organisms + poor growth
→ think immunodeficiency

The key exam skill is to identify which immune arm is defective:

Immune armMain infection pattern

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