№ 16Hematology18 min read
Multiple myeloma, Waldenström’s macroglobulinemia
1. Big picture
Multiple myeloma (MM) and Waldenström’s macroglobulinemia (WM) are both monoclonal B-cell/plasma-cell spectrum diseases, but they behave differently.
The exam shortcut is:
| Disease | Cell of origin | Main monoclonal protein | Classic clinical pattern |
|---|---|---|---|
| Multiple myeloma | Clonal plasma cells | Usually IgG, then IgA, or light chains |
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