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№ 16Metabolic Diseases17 min read

Lipid lowering treatment

1. Big picture

Lipid-lowering treatment is one of the most important preventive treatments in Internal Medicine because it reduces atherosclerotic cardiovascular disease (ASCVD): myocardial infarction, ischemic stroke, peripheral artery disease, and cardiovascular death. The examiner mainly wants you to know who needs treatment, what the LDL-cholesterol target is, which drug to start first, when to add ezetimibe or PCSK9 inhibition, and how to treat severe hypertriglyceridemia.

The central exam idea is:

LDL-cholesterol drives atherosclerosis → statins are first-line → intensify according to cardiovascular risk → severe triglycerides mainly kill by pancreatitis.

The Europea

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